{"id":2467,"date":"2019-03-22T17:31:34","date_gmt":"2019-03-22T17:31:34","guid":{"rendered":"https:\/\/live-lovette-lab.pantheonsite.io\/?p=2467"},"modified":"2019-03-22T17:31:34","modified_gmt":"2019-03-22T17:31:34","slug":"a-migration-gene-in-warblers","status":"publish","type":"post","link":"https:\/\/lovette.eeb.cornell.edu\/?p=2467","title":{"rendered":"A migration gene in warblers!"},"content":{"rendered":"

Just posted on BioaRxiv,<\/a> a pre-print of our new findings on genes associated with migration in warblers:<\/p>\n

Selection on VPS13A linked to long-distance migratory behavior in a songbird<\/strong><\/p>\n

David P. L.<\/span> Toews<\/span><\/span>, Scott A.<\/span> Taylor<\/span><\/span>, Henry M.<\/span> Streby<\/span><\/span>, Gunnar R.<\/span> Kramer<\/span><\/span>, Irby J.<\/span> Lovette<\/span><\/span><\/span><\/div>\n
\n
\n

Abstract<\/strong><\/p>\n

Animal migration demands an interconnected suite of physiological, behavioral, and neurological adaptations for individuals to successfully navigate and travel over long distances. This trait complex is especially crucial for small songbirds whose migratory behaviors–like directionality and orientation–are innate, rather than being learned as in many large, longer-lived birds. Identifying causal genes involved in these traits has been a central goal of migration ecology, and this endeavor has been furthered by genome-scale comparisons. However, even the most successful studies of migration genetics have only achieved low resolution associations, identifying large chromosomal regions, across multiple haplotype blocks, that encompass hundreds of putatively causal genes. Here we leverage the extreme genomic similarity among golden-winged (Vermivora chrysoptera) and blue-winged warblers (Vermivora cyanoptera) to identify a single gene–Vacuolar Protein Sorting 13 Homolog A (VPS13A)–that is associated with distinct differences in migration directionality to Central American (CA) versus South American (SA) wintering areas. Moreover, we find significantly reduced sequence variation in this gene-region for SA wintering birds, and show this is the result of strong natural selection on this gene. In humans, VPS13A codes for chorein, and variants of this gene are associated with the neurodegenerative disorder chorea-acanthocytosis. This new association provides the strongest gene-level linkage for avian migration directionality, and further interrogation of this gene will allow for a better understanding of its role in neuro-muscular processes across vertebrates.<\/p><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Just posted on BioaRxiv, a pre-print of our new findings on genes associated with migration in warblers: Selection on VPS13A linked to long-distance migratory behavior in a songbird David P. L. Toews, Scott A. Taylor, Henry M. Streby, Gunnar R. Kramer, Irby J. Lovette Abstract Animal migration demands an interconnected\u2026<\/p>\n

Continue reading<\/i><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-2467","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nA migration gene in warblers! - Lovette Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lovette.eeb.cornell.edu\/?p=2467\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A migration gene in warblers! - Lovette Lab\" \/>\n<meta property=\"og:description\" content=\"Just posted on BioaRxiv, a pre-print of our new findings on genes associated with migration in warblers: Selection on VPS13A linked to long-distance migratory behavior in a songbird David P. L. Toews, Scott A. Taylor, Henry M. Streby, Gunnar R. Kramer, Irby J. Lovette Abstract Animal migration demands an interconnected\u2026 Continue reading\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lovette.eeb.cornell.edu\/?p=2467\" \/>\n<meta property=\"og:site_name\" content=\"Lovette Lab\" \/>\n<meta property=\"article:published_time\" content=\"2019-03-22T17:31:34+00:00\" \/>\n<meta name=\"author\" content=\"Irby Lovette\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Irby Lovette\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/lovette.eeb.cornell.edu\/?p=2467\",\"url\":\"https:\/\/lovette.eeb.cornell.edu\/?p=2467\",\"name\":\"A migration gene in warblers! - Lovette Lab\",\"isPartOf\":{\"@id\":\"https:\/\/lovette.eeb.cornell.edu\/#website\"},\"datePublished\":\"2019-03-22T17:31:34+00:00\",\"author\":{\"@id\":\"https:\/\/lovette.eeb.cornell.edu\/#\/schema\/person\/23de1b0548ff273d55f8c3d941de3a67\"},\"breadcrumb\":{\"@id\":\"https:\/\/lovette.eeb.cornell.edu\/?p=2467#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/lovette.eeb.cornell.edu\/?p=2467\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/lovette.eeb.cornell.edu\/?p=2467#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lovette.eeb.cornell.edu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A migration gene in warblers!\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lovette.eeb.cornell.edu\/#website\",\"url\":\"https:\/\/lovette.eeb.cornell.edu\/\",\"name\":\"Lovette Lab\",\"description\":\"and The Fuller Evolutionary Biology Program\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lovette.eeb.cornell.edu\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/lovette.eeb.cornell.edu\/#\/schema\/person\/23de1b0548ff273d55f8c3d941de3a67\",\"name\":\"Irby Lovette\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/lovette.eeb.cornell.edu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/22f03cdfed1793d425b72bdabd3415196e135dd1ca340132335491ab19f1da7a?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/22f03cdfed1793d425b72bdabd3415196e135dd1ca340132335491ab19f1da7a?s=96&d=mm&r=g\",\"caption\":\"Irby Lovette\"},\"url\":\"https:\/\/lovette.eeb.cornell.edu\/?author=2\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A migration gene in warblers! - Lovette Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lovette.eeb.cornell.edu\/?p=2467","og_locale":"en_US","og_type":"article","og_title":"A migration gene in warblers! - Lovette Lab","og_description":"Just posted on BioaRxiv, a pre-print of our new findings on genes associated with migration in warblers: Selection on VPS13A linked to long-distance migratory behavior in a songbird David P. 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